New research suggests that individuals who stop using new weight-loss injections like semaglutide or tirzepatide can put back on shed pounds far faster than those who end traditional lifestyle regimens.
Findings released in a leading medical journal shows that while obese individuals often shed about a fifth of their body weight while undergoing treatment, the weight comes back at an estimated rate of nearly a kilo each month after stopping.
"Individuals purchasing these drugs need to be aware of the potential of quick rebound weight gain when the medication ends," stated lead investigator Dr. Susan Jebb.
That rate of regain means a reversion to starting mass within about a year and a half.
Analyzing Therapies
The research, which looked at dozens of trials involving over 9,000 of participants, contrasted the results of these new drugs with older methods.
Researchers emphasize that individuals who shed pounds through diet and exercise usually have a slower creep back—approximately 0.1 kg a month—after stopping.
Explaining the Rapid Regain
Experts propose the mechanism of the drugs accounts for the heightened regain.
GLP-1 drugs imitate a natural hormone called glucagon-like peptide-1, which moderates hunger.
"Sustained high doses of GLP-1 levels far above than the body's typical production might result in the system to produce less of its own natural hormone, and may also lessen sensitivity to its effects," noted Dr. Adam Collins, a nutrition specialist.
"Stopping of this medication means hunger is uncontrolled, making binge eating much more probable."
A Lifelong Disease?
The NHS recommend the jabs for individuals with weight-linked medical conditions, alongside recommended lifestyle changes.
A number of clinicians say that, given the significant potential of weight regain, the treatment is often ongoing.
This perspective is supported by pharmaceutical companies, who state that the results "highlight the chronic nature of excess weight," akin to managing diseases like diabetes.
User Experiences
People who have come off the medication report a sudden resurgence of hunger.
"It was like something activating and you're instantly ravenous," recalled an individual.
The struggle is exacerbated if individuals have not developed permanent lifestyle or habit modifications during treatment.
Widespread Adoption
Survey data suggest that millions of adults in the UK have used weight-loss jabs in the past year, with desire being substantial.
- Adoption is greater among women than men.
- The middle-aged demographic shows the greatest usage rates.
- Many access the medications through private healthcare rather than public health services.
Finally, researchers stress that while the jabs are effective tools for weight loss, they are not a standalone solution and lasting health benefits relies on integrated behavioural support.
